The Best Twitter Client for Windows Desktop
Snitter, Spaz and Twhirl are pretty good desktop clients for Twitter - all of them use the Adobe AIR platform and can therefore run on Mac and Windows.
They are all very similar in features but if I were to pick one of the three, I would probably go with Twhirl - it sports the most elegant interface of them all and you can add multiple Twitter accounts.
Hover the mouse over the avatars of your Twitter friends and you get access to various options like direct messages, replies, etc.
And Twhirl is probably the only Twitter client that lets me change the font of tweets. Thanks Tamar.

Snitter is an HTML app, so you can use the User Styles screen to apply any CSS to the interface. To change the font, you can add something like this:
.tweettext {
font-family:”Calibri”;
font-size:16px;
line-height:1.2;
}
Thanks for the mention!
I’ve used Snitter and feel it has a very cool and friendly user interface. Now I am going to check Thwirl based on your recommendations.
Adobe Air didn’t play nice on my win xp machine. Installed it but when I tried to install the programs I got the blue screen of death. After 3 blues, uninstalled! boo adobe air.
I really liked Snitter. However my issue is with any Adobe Air application - if i leave one running for a few days on my laptop, it continuously consumes RAM/Virtual Memory with no end in sight!
I’m a big Twhirl fan, I use it on both my macbook and dell laptop. If you’re following over 500 friends on twitter it works great vs other twitter apps that hangs when trying to pull down tweets. You can also follow and communicate with the Twhirl developer on twitter his id is twitter.com/twhirl and mine is twitter.com/waynesutton